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Nclinical data on xposd pgnancis a availabl toicoxib. Studis in animals hav shown poductiv toxicity (s sction 5.3). Th potntial human isk in pgnancy is unknown. toicoxib, as with oth mdicinal poducts inhibiting postaglandin synthsis, may caus utin intia and pmatu closu th ductus atiosus duing th last timst. toicoxib is containdicatd in pgnancy (s sction 4.3). I a woman bcoms pgnant duing tatmnt, toicoxib must b discontinud.
Taditional NSAIDs block th actions twtyps COX nzyms, COX-1 and COX-2. COX-1 contibuts tinlammation but it alshlps potct th lining th stomach, sblocking COX-1 maks th stomach vulnabl tinjuy. Acoxia mainly blocks COX-2, sit is lss likly tcaus stomach ulcs associatd with oth NSAIDs.
Th dcision tpscib a slctiv COX-2 inhibitshould b basd on an assssmnt th individual patint’s ovall isks (s sctions 4.3, 4.4).
You doctwill want discuss you tatmnt with Acoxia om tim ttim. It is impotant that you us th lowst dos that contols you pain and you should not tak Acoxia long than ncssay. This is bcaus th isk hat attacks and stoks might incas at polongd tatmnt, spcially with high doss.
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arcoxia does not block cox-1, the enzyme involved in protecting the stomach from ulcers.